Even with the best hand, if you don't understand the rules of the game, you can still lose. Someone might look poised to succeed in life with his educational background, a good job and great health but if his mentality and actions do not maximize these advantages, failure is inevitable. We always seemed surprised to hear people succeeding out of no where. But if we look closely, a lot of those who reach the top are the ones who started out from the bottom yet hustle their way up against the odds.
Remember that the person who is more likely to succeed is not always the one who's dealt with the best hands in life but it is he who strategizes his way up no matter how bad the set of cards are being dealt against him.